The 1980-81 Iowa State Cyclones went 9-18 (2-12 in the Big 8) under head coach Johnny Orr. Simple Rating System: -0.12.
| Date | Opponent | Result | Arena |
|---|---|---|---|
| 1980-12-01 | at Vanderbilt Commodores | L 87–97 | Memorial Gymnasium |
| 1980-12-04 | vs Drake Bulldogs | W 74–72 | James H. Hilton Coliseum |
| 1980-12-06 | vs Northern Iowa Panthers | W 83–69 | James H. Hilton Coliseum |
| 1980-12-09 | at SMU Mustangs | L 55–58 | Moody Coliseum |
| 1980-12-12 | vs Creighton Bluejays | L 73–77 | James H. Hilton Coliseum |
| 1980-12-20 | at Iowa Hawkeyes | L 59–85 | Iowa Field House |
| 1980-12-23 | vs UAB Blazers | W 71–70 | James H. Hilton Coliseum |
| 1980-12-29 | neutral East Carolina Pirates | W 80–73 | New Haven Coliseum |
| 1980-12-30 | at Fairfield Stags | W 47–46 | Alumni Hall |
| 1981-01-14 | at Kansas Jayhawks | L 58–70 | Allen Fieldhouse |
| 1981-01-17 | at Missouri Tigers | L 69–92 | Hearnes Center |
| 1981-01-19 | at Saint Louis Billikens | L 59–61 | St. Louis Arena |
| 1981-01-21 | vs Oklahoma Sooners | W 88–67 | James H. Hilton Coliseum |
| 1981-01-24 | at Oklahoma State Cowboys | L 75–81 | Gallagher Hall |
| 1981-01-28 | vs Nebraska Cornhuskers | L 56–61 | James H. Hilton Coliseum |
| 1981-01-31 | vs Kansas State Wildcats | L 62–75 | James H. Hilton Coliseum |
| 1981-02-04 | at Colorado Buffaloes | L 63–73 | Coors Events/Conference Center |
| 1981-02-07 | vs Missouri Tigers | L 56–70 | James H. Hilton Coliseum |
| 1981-02-10 | at Oklahoma Sooners | L 66–78 | Lloyd Noble Center |
| 1981-02-14 | vs Kansas Jayhawks | L 49–51 | James H. Hilton Coliseum |
| 1981-02-18 | at Nebraska Cornhuskers | L 61–81 | Bob Devaney Sports Center |
| 1981-02-21 | vs Oklahoma State Cowboys | L 69–76 | James H. Hilton Coliseum |
| 1981-02-25 | at Kansas State Wildcats | L 60–67 | Ahearn Field House |
| 1981-02-28 | vs Colorado Buffaloes | W 67–56 | James H. Hilton Coliseum |
| 1981-03-03 | at Missouri Tigers | L 70–95 | Hearnes Center |
Iowa State Cyclones program history · All Division I programs · Hoopsipedia home
| Rank | Team | Conference | All-Time Wins |
|---|
Top 100 by all-time D1 wins. Verified against the NCAA record book — and tiered so you can argue properly.
| # | COACH | RECORD | WIN % | SCHOOL(S) | YEARS | BEST SEASON / LEGACY |
|---|