The 2021-22 Louisville Cardinals went 13-19 (6-14 in the ACC) under head coach Chris Mack,Mike Pegues. Simple Rating System: 4.23.
| Date | Opponent | Result | Arena |
|---|---|---|---|
| 2021-11-09 | vs Southern Jaguars | W 72–60 | KFC Yum! Center |
| 2021-11-12 | vs Furman Paladins | L 72–80 (OTOT) | KFC Yum! Center |
| 2021-11-15 | vs Navy Midshipmen | W 77–60 | KFC Yum! Center |
| 2021-11-20 | vs Detroit Mercy Titans | W 73–67 | KFC Yum! Center |
| 2021-11-25 | neutral Mississippi State Bulldogs | W 72–58 | Baha Mar Convention Center |
| 2021-11-27 | neutral Maryland Terrapins | W 63–55 | Baha Mar Convention Center |
| 2021-12-01 | at Michigan State Spartans | L 64–73 | Breslin Student Events Center |
| 2021-12-04 | at NC State Wolfpack | W 73–68 | PNC Arena |
| 2021-12-10 | vs DePaul Blue Demons | L 55–62 | KFC Yum! Center |
| 2021-12-14 | vs SE Louisiana Lions | W 86–60 | KFC Yum! Center |
| 2021-12-18 | at Western Kentucky Hilltoppers | L 72–82 | E. A. Diddle Arena |
| 2021-12-29 | vs Wake Forest Demon Deacons | W 73–69 | KFC Yum! Center |
| 2022-01-02 | at Georgia Tech Yellow Jackets | W 67–64 | McCamish Pavilion |
| 2022-01-05 | vs Pittsburgh Panthers | W 75–72 | KFC Yum! Center |
| 2022-01-08 | at Florida State Seminoles | L 70–79 | Donald L. Tucker Civic Center |
| 2022-01-12 | vs NC State Wolfpack | L 63–79 | KFC Yum! Center |
| 2022-01-15 | at Pittsburgh Panthers | L 53–65 | Petersen Events Center |
| 2022-01-19 | vs Boston College Eagles | W 67–54 | KFC Yum! Center |
| 2022-01-22 | vs Notre Dame Fighting Irish | L 70–82 | KFC Yum! Center |
| 2022-01-24 | at Virginia Cavaliers | L 52–64 | John Paul Jones Arena |
| 2022-01-29 | vs Duke Blue Devils | L 65–74 | KFC Yum! Center |
| 2022-02-01 | vs North Carolina Tar Heels | L 83–90 (OTOT) | KFC Yum! Center |
| 2022-02-05 | at Syracuse Orange | L 69–92 | Carrier Dome |
| 2022-02-09 | at Notre Dame Fighting Irish | L 57–63 | Purcell Pavilion at the Joyce Center |
| 2022-02-16 | vs Miami (FL) Hurricanes | L 63–70 | KFC Yum! Center |
| 2022-02-19 | vs Clemson Tigers | W 70–61 | KFC Yum! Center |
| 2022-02-21 | at North Carolina Tar Heels | L 63–70 | Dean Smith Center |
| 2022-02-26 | at Wake Forest Demon Deacons | L 77–99 | Lawrence Joel Coliseum |
| 2022-03-01 | at Virginia Tech Hokies | L 43–75 | Cassell Coliseum |
| 2022-03-05 | vs Virginia Cavaliers | L 61–71 | KFC Yum! Center |
| 2022-03-08 | neutral Georgia Tech Yellow Jackets | W 84–74 | Barclays Center |
| 2022-03-09 | neutral Virginia Cavaliers | L 50–51 | Barclays Center |
Louisville Cardinals program history · All Division I programs · Hoopsipedia home
| Rank | Team | Conference | All-Time Wins |
|---|
Top 100 by all-time D1 wins. Verified against the NCAA record book — and tiered so you can argue properly.
| # | COACH | RECORD | WIN % | SCHOOL(S) | YEARS | BEST SEASON / LEGACY |
|---|